A number of actors played multiple roles within Prisoner (Cell Block H).
- Lois Ramsey played two characters, Agnes Foster and Ettie Parslow.
- Ian Smith - amongst various writing and production credits - played at least two characters, Ted Douglas and Pixie's priest father.
- Kirsty Child played Officer Anne Yates as well as Glynis Johnson, Fay Quinn's sister and later, Willie Beecham.
- Babs McMillan made her first appearance in Prisoner as divorce counsellor Miss Vaughan before playing Cass Parker.
- Julieanne Newbould made two appearances: Hannah Simpson and Wendy Glover.
- Margot Knight also made multiple appearances: her first playing Sharon Gilmour then much later as Officer Terri Malone.
- Ray Meagher played three antagonists: first portraying Geoff Butler, then Kurt Renner during Stevens' escape and finally as Blackmoor Governor Ernest Craven.
- Gerda Nicolson first portrayed Mrs Roberts, an officer at Barnhurst when Bea was sent there, before later going on to play Governor Ann Reynolds.
- Julie Blake played three characters over the run of Prisoner: herbalist Evelyn Randall, Alice Dodds and housewife Nancy McCormack.
- Anne Charleston first portrayed Mum's daughter Lorraine Watkins before portraying Reb Kean's mother, Diedre Kean as well as two unnamed police women in other episodes.
- Anne Phelan is known for playing Myra Desmond in later episodes but first portrayed Officer Manson and Bernadette in the beginning of Prisoner.
- Patty Burnett is known for her portrayal of Ida Brown but played Joyce Martin's Aunt Madge, a matron who visits Driscoll House and Margot, one of the elderly who live in the flats.
- Glennan Fahey first played Jack Gordon, a man from the country who met Bobbie Mitchell when she was on the run in Sydney as well as portraying Blackmoor prisoner Billy Slocum.
- Carl Bleazby was best known for playing Major Ferguson; Joan's father, but his first appearance is as the judge who sentenced Meg Morris to 3 days in Wentworth for Contempt of Court.
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